Acetic Acid → HCID 14052581, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 1-ethyl-6,7-difluoro-1,4-dihydro-8-methyl-4-oxo-3-quinolinecarboxylate (0.96 g), concentrated sulfuric acid (0.5 ml) and acetic acid (4 ml) in water (4 ml) was stirred for 70 minutes on an oil bath at 100° C. The reacting mixture was poured into ice-water (25 ml), the resulting precipitate was collected by filtration, washed with water sufficiently to give the title compound (0.8 g) as colorless flakes, mp 219°-221° C.

Provenance & Evidence