反应详情

温度

-20 °C

The mixture is cooled to -20° C. and the methyl ester (VII) (30 g; 0.134 mole) is added dropwise, at the end of which a saturated ammonium chloride solution is added slowly. The phases are separated, the organic phase is washed to neutrality yielding a pale yellow oil (40.7 g; yield=98%).

1. additionis added slowly
2. customThe phases are separated
3. washthe organic phase is washed
4. customto neutrality yielding a pale yellow oil (40.7 g; yield=98%)