反应详情

A potassium hydroxide (15 g, 0.27 mole) solution in methanol (30 ml) is added with a solution of ester (VIII) (50 g, 0.16 mole) in methanol (120 g). The reaction mixture is refluxed for 2 hours. It is then cooled and concentrated under reduced pressure, poured into water (200 ml) and acidified with conc. hydrochloric acid. It is then extracted with ethyl acetate (3×100 ml). The acid (IX) (13 g) is obtained. Yield=27%.

1. temperatureThe reaction mixture is refluxed for 2 hours
2. temperatureIt is then cooled
3. concentrationconcentrated under reduced pressure
4. additionpoured into water (200 ml)
5. extractionIt is then extracted with ethyl acetate (3×100 ml)