4-Methyl-5-(2-hydroxyethyl)thiazole → 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

Participants

Reaction Steps

71.6 g (500 millimoles) of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole), 63.3 g (500 millimoles) of freshly distilled benzyl chloride and 250 ml of absolute acetonitrile are refluxed for 24 hours in a 500 ml round-bottomed flask. The stirred reaction mixture is slowly cooled to room temperature, and the precipitate is filtered off under suction, washed colorless with dry acetonitrile, predried and then dried at 90° C. under reduced pressure from a water pump.

Provenance & Evidence