反应详情

A mixture of 172 g. (1.0 mole) methyl 2,2,4-trimethyl-3-ketovalerate, 5.4 g. (0.10 mole) sodium methoxide and 33 g. (0.36 mole) paraformalde in 250 ml. methanol is heated at reflux for eight hours. The mixture is quenched by addition of water, neutralized with hydrochloric acid, extracted with ethyl ether, washed with water, brine and solvent evaporated. The residue is purified by vacuum distillation or chromatography on silica gel to provide the purified product.

1. additionA mixture of 172 g
2. temperatureat reflux for eight hours
3. customThe mixture is quenched by addition of water
4. extractionextracted with ethyl ether
5. washwashed with water, brine and solvent
6. customevaporated
7. distillationThe residue is purified by vacuum distillation or chromatography on silica gel
8. customto provide the purified product