Methanol → HCID 14882506, compound

Participants

Reaction Steps

A solution of methyl 4-[6-(N-cyclopentyl-methylcarbamoylmethyl)indol-1-ylmethyl]-3-methoxybenzoate (1.34 g) in a combination of methanol (7.5 ml), tetrahydrofuran (7.5 ml), and water (3 ml) was treated with lithium hydroxide monohydrate (0.78 g). The mixture was stirred for 6 hr and then evaporated to remove the organic solvents. The resultant aqueous solution was acidified with 10% (v/v) hydrochloric acid. The white precipitate which formed was collected by filtration, washed with water, and dried under vacuum to give the title compound (0.70 g, 54%) as a white powder; mp 188°-189°.

Provenance & Evidence