2-Chlorobenzenesulfonamide → HCID 14882550, compound

HRID 330165Notes

Reaction equation

[O:1]=[C:2]([N:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1)/[CH:3]=[CH:4]/[C:5]1[C:13]2[C:8](=[CH:9][C:10](/[CH:14]=[CH:15]/[C:16]([N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[O:17])=[CH:11][CH:12]=2)[N:7]([CH2:23][C:24]2[CH:32]=[CH:31][C:27]([C:28]([OH:30])=O)=[CH:26][C:25]=2[O:33][CH3:34])[CH:6]=1.[Cl:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[S:47]([NH2:50])(=[O:49])=[O:48]>>[Cl:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[S:47]([NH:50][C:28](=[O:30])[C:27]1[CH:31]=[CH:32][C:24]([CH2:23][N:7]2[C:8]3[C:13](=[CH:12][CH:11]=[C:10](/[CH:14]=[CH:15]/[C:16]([N:18]4[CH2:19][CH2:20][CH2:21][CH2:22]4)=[O:17])[CH:9]=3)[C:5](/[CH:4]=[CH:3]/[C:2](=[O:1])[N:35]3[CH2:39][CH2:38][CH2:37][CH2:36]3)=[CH:6]2)=[C:25]([O:33][CH3:34])[CH:26]=1)(=[O:49])=[O:48]

Participants

Reactant 2

HCID 814102-Chlorobenzenesulfonamide

HCID 14882548HCID 14882548, compound

Product 1

HCID 14882550HCID 14882550, compound

Procedure

Using a similar procedure to that described in Example 32, except starting from E,E-4-[3,6-di-(3oxo-3-pyrrolidino-1-propenyl)indol-1-ylmethyl]- 3-methoxybenzoic acid, and using 2-chlorobenzenesulfonamide, title compound was obtained (87%) as powder, mp 291°-293°.

Sources & evidence

ORD record: ord-c0116ffd88a24a5da901d66dae972b14
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04894386

Reaction notes

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