Pyrrolidine → HCID 57078170, compound

Participants

Reaction Steps

Using a similar procedure to that described in Example 49, part g, except starting from methyl 4-[5-(2-carboxypropyl)-1-propylindol-3-ylmethyl]-3-methoxybenzoate, and using pyrrolidine instead of pentylamine, methyl 3-methoxy-4-[5-(2-methyl-3-pyrrolidino-3-oxopropyl)-1-propylindol-3-ylmethyl]benzoate was obtained (60%) as a colorless glass; partial NMR (250 MHz, DMSO-d6): 0.78(t, 3H, CH2CH3), 0.98(d, 3H, CH(CH3)), 1.4-1.8 (complex m, 6H), 2.6(m, 1H), 2.83(m, 4H), 3.3(complex m, 2H), 3.83(s, 3H, OCH3), 3.92(s, 3H, OCH3).

Provenance & Evidence