HCID 19870577, compound → HCID 19870615, compound

Participants

Reaction Steps

Methyl E-4-[6-(2-carboxyprop-1-enyl)-3-propylindol-1-ylmethyl]-3-methoxybenzoate (1.15 g) with palladium on carbon (10% w/w, 0.2 g) in dry tetrahydrofuran (50 ml) was hydrogenated at 2.0 bar. The mixture was filtered through a pad of diatomaceous earth and evaporated to give methyl 4-[6-(2-carboxypropyl)-3-propylindol-1-ylmethyl]-3-methoxybenzoate (1.12 g, 97%) as an oil; partial NMR (300 MHz, DMSO-d6): 0.93(t, 3H, CH2CH3), 0.98(d, 3H, CH(CH3)), 1.63(m, 2H, CH2CH3), 2.60(m, 4H, CH2CH2CH3, CHCH2), 2.96(m, 1H, CH(CH3)), 3.82(s, 3H, OCH3), 3.95(s, 3H, OCH3), 5.31(s, 2H, NCH2).

Provenance & Evidence