HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-(4-(Octyloxy)phenyl)pyrimidin-5-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Ethoxy-2-(4-octyloxyphenyl)pyrimidine | HCID 14496394 | — |
| Solvent | Diethylene Glycol | HCID 8117 | — |
| Product | 2-(4-(Octyloxy)phenyl)pyrimidin-5-ol | HCID 14496395 | 66.1% |
Reaction Steps
NaOH (58.4 g) was added to a solution of 5-ethoxy-2-(4-octyloxyphenyl)pyrimidine (48 g) dissolved in diethylene glycol (300 ml), followed by keeping the mixture at 220° C. for 3 hours, allowing the resulting material to cool down, adding water and acetic acid, filtering off deposited crystals, and recrystallizing from ethanol to obtain 5-hydroxy-2-(4-octyloxyphenyl)pyrimidine (29 g, m.p.: 131.2°-132.5° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04895671 |
| Source dataset | uspto-grants-1990_01 |
| ORD ID | ord-a498bef9631944c9bdfc288c20672c99 |
| Source note | uspto-grants-1990_01 |