反应详情

KOH (0.8 g) was added to a solution of 5-hydroxy-2-(4-octyloxyphenyl)pyrimidine (4 g) dissolved in ethanol (20 ml), followed by adding (S)-8-methyldecyl bromide (3.2 g) prepared according to the method disclosed in the literature (Mol. Cryst. Liq. Cryst., 1984, Vol. 114, pp. 237-247), keeping the mixture under reflux for 6 hours, allowing the resulting material to cool down, extracting it with toluene, washing the resulting organic layer with 2N-NaOH aqueous solution, further washing with water until the washing water became neutral, distilling off low-boiling components in the organic layer and recrystallizing the residue from ethanol to obtain the captioned compound, (S)-5-(8-methyldecyloxy)-2-(4-octyloxyphenyl)pyrimidine (1.8 g). Its phase transition points were as follows: ##STR12##

1. customprepared
2. temperatureunder reflux for 6 hours
3. temperatureto cool down
4. extractionextracting it with toluene
5. washwashing the resulting organic layer with 2N-NaOH aqueous solution
6. washfurther washing with water until the washing water
7. distillationdistilling off low-boiling components in the organic layer
8. customrecrystallizing the residue from ethanol