Dichloromethane → HCID 85556110, compound

HRID 330226Notes

Reaction equation

HRID 330226 reaction equation
C([NH:8][CH2:9][CH:10]([CH2:12][S:13][CH:14]([CH3:16])[CH3:15])[OH:11])(OC(C)(C)C)=O.C(Cl)[Cl:18]>>[NH2:8][CH2:9][CH:10]([CH2:12][S:13][CH:14]([CH3:16])[CH3:15])[OH:11].[ClH:18]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 131716253HCID 131716253, compound

Product 1

HCID 85556110HCID 85556110, compound

Procedure

BOC-NHCH2CH(OH)CH2SCH(CH3)2 (3.74 g, 0.015 mole) was dissolved in 75 ml CH2Cl2 and occasionally purged with HCl gas over two hours. The solvent was removed in vacuo, and the residue was triturated with Et2O. The solvent was decanted and the residue was stripped to a foam, 2.83 g. IR, NMR, and mass spectral analysis confirmed the structure.

Workup

  1. customoccasionally purged with HCl gas over two hours
  2. customThe solvent was removed in vacuo
  3. customthe residue was triturated with Et2O
  4. customThe solvent was decanted

Sources & evidence

ORD record
ord-d9dac2abfee148078775f620edc16bb6
Source dataset
uspto-grants-1990_01
Patent number
US04895834

Reaction notes

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