Hydroxyamine hydrochloride → HCID 54444278, compound

Participants

Reaction Steps

A stirred mixture of NaOMe (25 wt % in MeOH, 11.3 mL, 0.0493 mol), MeOH (40 mL), and hydroxylamine hydrochloride (3.4 g, 0.0493 mol) was heated under reflux for 1 hour. 7-Chloro-3-benzofuranylacetonitrile (6.3 g, 0.0329 mol) and MeOH (15 mL) were added and heating was continued for 2 days. The mixture was concentrated, suspended in H2O, and filtered. The solid was triturated with ether to give the product (5.4 g, 73%) as a tan solid, m.p. 142°-145° C.

Provenance & Evidence