Hydroxyamine hydrochloride → HCID 85607801, compound

Participants

Reaction Steps

To a stirred solution of hydroxylamine hydrochloride (3.86 g, 0.056 mol) in MeOH (100 mL) was added sodium methoxide (25 wt % in MeOH, 10.33 g, 0.056 mol). Stirring was continued for 15 minutes and 5-bromo-2-benzthiophenylacetonitrile (7.0 g, 0.028 mol) was added. The resulting mixture was refluxed for 2 days, cooled, and concentrated. The residue was diluted with H2O. The solid was collected by filtration, purified by column chromatography (eluant: EtOAc/hexane, 2:3) to give 4.0 g (50%) of product as a white solid.

Provenance & Evidence