Bromocyclopropane → HCID 17977197, compound

Participants

Reaction Steps

A mixture of 3.6 g (0.03 mole) of cyclopropyl magnesium bromide prepared from cyclopropyl bromide and 0.8 g (0.033 mole) of magnesium in 50 ml of dry T.H.F. was added dropwise to a suspension of 3.9 g (0.0177 mole) of 7-methoxy-imidazo[2,1-b]benzothiazole-2carboxaldehyde in 80 ml of dry T.H.F. The mixture was stirred at room temperature for 3 hours and was quenched with saturated aqeous ammonium chloride solution. The mixture was extracted with ethyl acetate and the extracts were dried over magnesium sulfate and evaporated under reduced pressure. The residue was chromatographed on silica gel and eluted with 2% methanol/dichloromethane to obtain 2.75 g (69% yield) of [7-methoxy-imidazo[2,1-b]benzothiazol-2-yl) cyclopropyl methanol as colorless solid melting at 151° to 153° C.

Provenance & Evidence