HCID 13304948, compound → HCID 19989904, compound

HRID 330300Notes

Reaction equation

HRID 330300 reaction equation
[CH2:1]([C:3]1[C:4]([O:15][CH3:16])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)[C:8]=1[CH3:9])[CH3:2].[O:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[O:23][CH2:24][C:25]#[C:26][Mg]Br>>[CH2:1]([C:3]1[C:4]([O:15][CH3:16])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([C:13](=[O:14])[C:26]#[C:25][CH2:24][O:23][CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][O:17]3)[N:12]=2)[C:8]=1[CH3:9])[CH3:2]

Participants

3

Reactant 2

HCID 13304948HCID 13304948, compoundHCID 178419646HCID 178419646, compound

Product 1

HCID 19989904HCID 19989904, compound

Procedure

6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-carboxaldehyde and 3-(tetrahydropyran-2-yloxy)-1-propynyl-magnesium bromide [J. Chem. Soc., 1950, 3646] were reacted by the method of Step A of Example 1 to obtain 1-(6-ethyl-7-methoxy-5-methylimidazol[1,2-a]pyrimidin-2-yl)-4-(tetrahydropyran-2-yloxy)-2-butyn-1-one.

Sources & evidence

ORD record
ord-cae4c9cd73494e628bc09d6e3a2311d8
Source dataset
uspto-grants-1990_01
Patent number
US04895866

Reaction notes

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