HRID33033

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Br)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

HCID67422060

未命名化合物

结构：CCOC(=O)C1=C(c2ccc(OCCOc3cccc(F)c3Cl)cc2)CC2CN(C(C)=O)CC1N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

HCID69302008

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

HCID67420793

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

As described for compound BN2, but from bicyclononene BM10 (2.82 g, 3.94 mmol), aq. 1M NaOH (30 mL) and EtOH (70 mL). The crude title compound (1.90 g, 74%) was used ftther without purification.

WORKUP

后处理

customThe crude title compound (1.90 g, 74%) was used ftther without purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2332f716a30042dfad44534e29d04ebd
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07427613B2
来源说明: uspto-grants-2008_09

反应 SMILES

[Cl:1][C:2]([Cl:43])([Cl:42])[C:3]([O:6][C:7]([N:9]1[CH:14]2[C:15]([C:36]([OH:38])=[O:37])=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][O:27][C:28]4[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:29]=4Br)=[CH:20][CH:19]=3)[CH2:17][CH:10]1[CH2:11][N:12]([C:39](=[O:41])[CH3:40])[CH2:13]2)=[O:8])([CH3:5])[CH3:4].[Cl:44]C(Cl)(Cl)C(OC(N1C2C(C(OCC)=O)=C(C3C=CC(OCCOC4C=CC=C(F)C=4Cl)=CC=3)CC1CN(C(=O)C)C2)=O)(C)C.[OH-].[Na+]>CCO>[Cl:1][C:2]([Cl:43])([Cl:42])[C:3]([O:6][C:7]([N:9]1[CH:14]2[C:15]([C:36]([OH:38])=[O:37])=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][O:27][C:28]4[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:29]=4[Cl:44])=[CH:20][CH:19]=3)[CH2:17][CH:10]1[CH2:11][N:12]([C:39](=[O:41])[CH3:40])[CH2:13]2)=[O:8])([CH3:5])[CH3:4]