3-Phenylprop-2-Enal → 1-(5-Phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one

Participants

Reaction Conditions

Reaction Steps

To 10 ml of diphenyl ether were added 1.3 g of cinnamaldehyde and 0.8 g of acetylhydrazine, followed by gradual heating to 220° C. over 30 minutes. Stirring was continued for 3 hours at that temperature. After cooling, the reaction liquid as such was subjected to silica gel chromatography (chloroform/methanol=100/1). Thus there was obtained 1.2 g of 1-acetyl-5-phenyl-2-pyrazoline in the form of light yellowish oil as the desired product. The yield was 64.8%.

Provenance & Evidence