Hydrogen Bromide → 2-Amino-3-chloro-5-pyridyl bromomethyl ketone

Participants

Reaction Steps

16 g (0.1 mol) of bromine are added dropwise to a solution of 17.0 g (0.1 mol) of 2-amino-3-chloro-5-acetylpyridine in a mixture of 19.3 g of hydrogen bromide (47% strength aqueous solution; 0.11 mol) and 500 ml of glacial acetic acid. The mixture is subsequently stirred for two hours, brought to pH 8 and extracted with ethyl acetate. Drying and evaporation gives 18.5 g (74%) of the title compound, melting point 134° C. Example of the preparation of the pyridyl-aminomethyl ketones

Provenance & Evidence