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(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride → 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride | HCID 3080792 | — |
| 反応物 | Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester | HCID 4377704 | — |
| 生成物 | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
反応手順
The resulting product was esterified with (R)α-methoxy-α-trifluoromethylphenylacetyl chloride, and the ester was analyzed by HPLC. From the area ratio of the chromatogram, the optical yield of the product was found to be 97.2% ee.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04895979 |
| 出典データセット | uspto-grants-1990_01 |
| ORD ID | ord-e77df226a15942e0a532ac81d947a918 |
| 出典メモ | uspto-grants-1990_01 |