Hydrochloric Acid → HCID 19868623, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 8,10-bis[(aminoacetyl)oxy]-11-methyl-1,2,3,4-tetrahydro-6H-benzo[b]quinolizine-6-one (0.92 g) in dry dichloromethane (100 ml), and pass a stream of hydrogen chloride gas through the solution for 45 min. at ambient temperature (about 25° C.). Stir the resulting mixture at 25° C. for 2 hours, and filter to collect the precipitated crystals. Wash the collected crystals with ether and acetone, and dry and crystallize them to obtain 8,10-bis[(aminoacetyl)oxy]-11-methyl-1,2,3,4-tetrahydro-6H-benzo[b]quinolizine-6-one dihydrochloride, m.p. 202°-205° C. (from MeOH-ether, as a hemihydrate).

Provenance & Evidence