HCID 19868639, compound → HCID 19868640, compound

Participants

Reaction Conditions

Reaction Steps

Add pyridinium chlorochromate (2.96 g) and 3Å, 1/16-inch molecular sieves (2.96 g) to a solution of 1-[3,5-bis(acetyloxy)benzoyl]-α-phenyl-2-piperidinemethanol (2.66 g) in dry dichloromethane (60 ml). Stir the resulting mixture at 23° C. for 4 hours. Filter the mixture through diatomaceous earth, and concentrate the filtrate. Chromatograph the residue over silica gel, and elute the column with 10% ethyl acetate in chloroform. Combine appropriate fractions, concentrate them, and crystallize the residue to obtain 2-benzoyl-1-[3,5-bis(acetyloxy)benzoyl]-piperidine, m.p. 77°-79° C. (from ether-pet. eth.).

Provenance & Evidence