Propyl mercaptan → 5-Propylthio-pyrrolidin-2-one

HRID 330505Notes

Reaction equation

HRID 330505 reaction equation
C(O[CH:4]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5]1)C.[CH2:10]([SH:13])[CH2:11][CH3:12]>>[CH2:10]([S:13][CH:4]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5]1)[CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 7848Propyl mercaptanHCID 35805555-Ethoxy-2-pyrrolidinone

Product 1

HCID 198687015-Propylthio-pyrrolidin-2-one

Procedure

A mixture of 4 g of 5-ethoxy-pyrrolidin-2-one, 30 cm3 of propanethiol and 2 g of Amberlite-15 resin is agitated for 2 hour 45 minutes at ambient temperature. The resin is filtered off, then the excess propanethiol is distillated. 2.8 g of the expected product is obtained, isolated from isopropyl ether. m.p. 40°-42° C.

Workup

  1. filtrationThe resin is filtered off

Sources & evidence

ORD record
ord-60b673ed23b0436780184f18104d982b
Source dataset
uspto-grants-1990_01
Patent number
US04897414

Reaction notes

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