反应详情

Potassium hydroxide (25.3 g, 0.45 mol) was added to a solution of 1-bromo-2-naphthalenemethanol acetate (105 g, 0.38 mol) in methanol (300 mL) at room temperature. The resulting yellow solution was stirred at room temperature for 3 hours, then diluted with water and a precipitate was formed. The mixture was extracted with ether (2×300 mL), and the combined organic layers were washed with water (250 mL), brine, dried over anhydrous magnesium sulfate and concentrated in vacuo. The pure product was obtained as a light yellow solid (86.8 g, 96%).

1. customa precipitate was formed
2. extractionThe mixture was extracted with ether (2×300 mL)
3. washthe combined organic layers were washed with water (250 mL), brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated in vacuo