Potassium Hydroxide → HCID 15624012, compound

Participants

Reaction Steps

A mixture of 20.5 parts of ethyl 4-[[1-[(5-methyl-2-furanyl)methyl]-1H-imidazo[4,5-c]pyridin-2-yl]amino]-1-piperidinecarboxylate, 40 parts of potassium hydroxide and 240 parts of 2-propanol was stirred overnight at reflux temperature. After evaporation, the residue was taken up in water and the product was extracted with dichloromethane. The extract was dried, filtered and evaporated. The residue was crystallized from 2-propanone. The product was filtered off and dried, yielding 15 parts (88%) of 1-[(5-methyl-2-furanyl)methyl]-N-(4-piperidinyl)-1H-imidazo[4,5-c]pyridin-2-amine; mp. 185.6° C. (int. 25).

Provenance & Evidence