6-(4-Hydroxyphenyl)hexanoic acid → HCID 178525431, compound

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Reaction Steps

6-(4-Hydroxyphenyl)hexanoic acid (2 g) is subjected to catalytic reduction in the presence of 5% rhodium-carbon (500 mg) in ethanol (100 ml) at an initial hydrogen pressure of 10.1 kg/cm2. The catalyst is filtered off and the filtrate is concentrated under reduced pressure and subjected to silica gel column chromatography. Elution is carried out with 4% ethanol-chloroform to give three fractions. The first fraction is recrystallized from ether-ligroin to give 392 mg of cis-6-(4-hydroxycyclohexyl)hexanoic acid, m.p. 83°-85° C.

Provenance & Evidence