p-Toluenesulfonic acid → HCID 178476591, compound

Participants

Reaction Steps

trans-7-(4-Hydroxycyclohexyl)heptanoic acid (6.5 g) and p-toluenesulfonic acid (15 mg) are stirred in acetic anhydride (32.5 ml) at 60°-70° C. for 1.5 hours. The excess acetic anhydride is distilled off under reduced pressure, followed by addition of water (90 ml), and the mixture is stirred for 3 days. The resulting crystalline precipitate is collected by filtration and recrystallized from ethyl acetate-hexane to give 6.5 g of trans-7-(4-acetoxycyclohexyl)heptanoic acid as colorless needless, m.p. 66°-68° C.

Provenance & Evidence