참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Acetone Cyanohydrin | HCID 6406 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,7-Dichloro-heptan-4-one | HCID 246749 | — |
| 생성물 | hexahydro-1H-pyrrolizine-7a-carbonitrile | HCID 11029899 | 89% |
반응 단계
To a solution of aceton cyanohydrin (2.3 g, 27 mmol) saturated with ammonia, 1,7-dichloro-4-heptanone (0.50 g, 2.7 mmol) was added dropwise at 20° C. The resulting solution was stirred for 48 hours at 20° C. under ammonia gas atmosphere. To the reaction mixture, 0.1N-NaOH was added to extract with methylene chloride. The extract was dried over anhydrous sodium sulfate, concentrated and distilled in vacuo to afford 0.33 g of the desired compound (Yield: 89%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04897495 |
|---|
| 출처 데이터셋 | uspto-grants-1990_01 |
|---|
| ORD ID | ord-a85465a5215648fdaf2a095d239f17e5 |
|---|
| 출처 메모 | uspto-grants-1990_01 |
|---|
