Hydrochloric Acid → HCID 22820170, compound

Participants

Reaction Steps

10 g (0.11 mol) of 45% strength sodium hydroxide solution are added dropwise at 20° to 25° C. during the course of 30 minutes to a suspension of 7 g (0.02 mol) of 4,4-di-methyl-1,3-dichloro-6-chloro-1-(4-chlorophenyl)-hex-1-en-5-one in 20 ml of methanol. The reaction is subsequently stirred for 3 hours at 35° to 40° C. After neutralization using concentrated hydrochloric acid, the main amount of methanol is removed by evaporation in vacuo. The solution remaining is adjusted to pH 3 using concentrated hydrochloric acid, extracted using toluene at 40° C. and the solvent is stripped off. 5.36 g (94% of theory) of cis/trans-3-(Z-2-chloro-2-(4-chlorophenyl)-vinyl-2,2-dimethylcyclopropanecarboxylic acid are obtained.

Provenance & Evidence