HCID 86743723, compound → HCID 15927705, compound

HRID 330624Notes

Reaction equation

HRID 330624 reaction equation
C([O:5][C:6](=[O:49])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:48])[C@H:13]([CH2:36][CH2:37][CH2:38][CH2:39][NH:40]C(OC(C)(C)C)=O)[NH:14][C@H:15]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH:23]C(OC(C)(C)C)=O)(C)(C)C>C(O)=O>[CH2:34]([O:33][C:31]([C@@H:15]([NH:14][C@H:13]([C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:49])=[O:5])=[O:48])[CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][NH2:23])=[O:32])[CH3:35]

Participants

3

Reactant 1

HCID 86743723HCID 86743723, compound

Product 1

HCID 15927705HCID 15927705, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
37 °C

Procedure

Nα -[1(S)-ethoxycarbonyl-8-tertiary butoxycarbonylaminooctyl]-Nε -tertiary butoxycarbonyl-L-lysyl-L-proline tertiary butylester obtained by Example VII b) (480 mg) is added into 100 ml of formic acid and dissolved. This solution is stirred at 37° C. for 48 hours. The formic acid is distilled off and the residue is dried under reduced pressure to obtain 320 mg of colorless oil.

Workup

  1. dissolutiondissolved
  2. distillationThe formic acid is distilled off
  3. customthe residue is dried under reduced pressure

Sources & evidence

ORD record
ord-f66c253117f142d6b446a400a8d8d24c
Source dataset
uspto-grants-1990_01
Patent number
US04897483

Reaction notes

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