HCID 14539524, compound → HCID 14723845, compound

HRID 330630Notes

Reaction equation

HRID 330630 reaction equation
FC1C=CC(C(C2C=CC(F)=CC=2)=C(C2N(C)N=NN=2)C(O)=O)=CC=1.[F:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:44]2[CH:49]=[CH:48][C:47]([F:50])=[CH:46][CH:45]=2)=[C:34]([C:38]2[N:39]=[N:40][N:41]([CH3:43])[N:42]=2)[C:35](O)=[O:36])=[CH:29][CH:28]=1>>[F:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([C:44]2[CH:45]=[CH:46][C:47]([F:50])=[CH:48][CH:49]=2)=[C:34]([C:38]2[N:39]=[N:40][N:41]([CH3:43])[N:42]=2)[CH:35]=[O:36])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 14539524HCID 14539524, compoundHCID 14723822HCID 14723822, compound

Product 1

HCID 14723845HCID 14723845, compound

Procedure

The general procedure of Steps A, B, and C of Example 6 was repeated, except that the 3,3-bis(4-fluorophenyl)-2-(1-methyl-1H-tetrazol-5-yl)-2-propenoic acid utilized in Step A was replaced by 3,3-bis(4-fluorophenyl)-2-(2-methyl-2H-tetrazol-5-yl)-2-propenoic acid [prepared in Example 5] to yield the title compound as a gummy solid in 76% overall yield. MS (CI): m/e=326 for (M+H)+.

Sources & evidence

ORD record
ord-b86ac7a3687f4fe69347a912aee138bf
Source dataset
uspto-grants-1990_01
Patent number
US04897490

Reaction notes

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