HCID 13911071, compound → HCID 88594862, compound

HRID 330710Notes

Reaction equation

HRID 330710 reaction equation
[C:1](/[CH:3]=[CH:4]/[CH2:5][C:6](O)=[S:7])#[N:2].[NH2:9][C@H:10]1[CH2:14][O:13][N:12]([C:15]2([C:21]([O:23][CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:22])[CH2:19][CH2:18][C:17](=[O:20])[O:16]2)[C:11]1=[O:37]>>[C:1](/[CH:3]=[CH:4]/[CH2:5][C:6]([NH:9][C@H:10]1[CH2:14][O:13][N:12]([C:15]2([C:21]([O:23][CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:22])[CH2:19][CH2:18][C:17](=[O:20])[O:16]2)[C:11]1=[O:37])=[S:7])#[N:2]

Participants

3

Reactant 2

HCID 13911071HCID 13911071, compoundHCID 178511019HCID 178511019, compound

Product 1

HCID 88594862HCID 88594862, compound

Procedure

A procedure similar to Example 1 (a), using 143 mg of (E)-2-cyanovinylthioacetic acid and 300 mg of benzhydryl ester of a deacetyl compound of TAN-588, gave 284 mg of benzhydryl 2-((4S)-4-[(E)-2-cyanovinylthioacetamido]-3-oxo-2-isoxazolidinyl]-5-oxo-2-tetrahydrofurancarboxylate.

Sources & evidence

ORD record
ord-1f64f2964c6e47279c194ba969fb7fa9
Source dataset
uspto-grants-1990_01
Patent number
US04897489

Reaction notes

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