HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylamine → (rac.)-(1R*,5S*)-3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid (6-chlorobenzo[1,3]-dioxol-5-ylmethyl)cyclopropylamide formate salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylamine | HCID 67419247 | — |
| Reactant | 3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester | HCID 67420793 | — |
| Product | (rac.)-(1R*,5S*)-3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid (6-chlorobenzo[1,3]-dioxol-5-ylmethyl)cyclopropylamide formate salt | HCID 131727073 | — |
Reaction Steps
Synthesized according to typical procedures H and E from bicyclononene BN10 and (6-chlorobenzo[1,3]dioxol-5-ylmethyl)cyclopropylamine. LC-MS: Rt=0.90; ES+: 684.19.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427613B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-912cb49b0d2d41ffa21c8e1383418daa |
| Source note | uspto-grants-2008_09 |