5-Amino-2-methoxyphenol → N-[4-methoxy-3-(2-phenoxy-ethoxy)-phenyl]-acetamide

HRID 330784Notes

Reaction equation

HRID 330784 reaction equation
NC1C=CC(OC)=[C:6]([OH:8])C=1.C[C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[CH:14][C:13]=1[O:22][CH2:23][CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH3:6][O:8][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[CH:14][C:13]=1[O:22][CH2:23][CH2:24][O:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 743145-Amino-2-methoxyphenolHCID 86684778N-[4-methyl-3-(2-phenoxy-ethoxy)-phenyl]-acetamide

Product 1

HCID 86684779N-[4-methoxy-3-(2-phenoxy-ethoxy)-phenyl]-acetamideYield 62%

Procedure

The compound 19a was prepared starting from 5-amino-2-methoxy phenol (800 mg, 5.75 mmol) according to the procedure described for the synthesis of 18a (as in Example 27) in 62% yield as white powder.

Sources & evidence

ORD record
ord-a850d830de6642eabd903b98dc6331d2
Source dataset
uspto-grants-2014_11
Patent number
US08877752B2

Reaction notes

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