HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → N-[4-chloro-3-(2-morpholin-4-yl-ethoxy)-phenyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | N-(4-Chloro-3-hydroxyphenyl)acetamide | HCID 14122483 | — |
| Product | N-[4-chloro-3-(2-morpholin-4-yl-ethoxy)-phenyl]-acetamide | HCID 86684780 | 69% |
Reaction Steps
The compound 23a was prepared by using the general procedure H, as given in Example 9, in 69% yield starting from 17a, with 2.5 eq of cesium carbonate and 1.1 eq of 4-(2-chloroethyl) morpholine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877752B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-b7ec9259fc1742a1a147474dad6ba6dd |
| Source note | uspto-grants-2014_11 |