HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 330800Generated: October 30, 2026
Water → 3-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one
https://huagongshe.com/reaction/330800
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(Trifluoromethyl)benzo[d]thiazol-2(3H)-one | HCID 13227340 | — |
| Reactant | 4-{2-[2-(3-Chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochloride | HCID 66985501 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one | HCID 46700771 | — |
Reaction Steps
A suspension of 89 mg (0.405 mmol) of 5-trifluoromethyl-3H-benzothiazol-2-one, 150 mg (0.405 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yl-oxy]ethyl}morpholine hydrochloride and 286 mg (2.02 mmol) of potassium carbonate in 8 ml of acetonitrile are stirred at 70° C. for 5 days. 30 ml of water are added to the reaction mixture, with a precipitate slowly forming. The precipitate is filtered off with suction, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08877751B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-d6e890e927a2402ab0aae87c0d87fe88 |
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| Source note | uspto-grants-2014_11 |
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