Sodium Hydroxide → HCID 23219055, compound

HRID 330815Notes

Reaction equation

HRID 330815 reaction equation
C([O:3][C:4](=[O:20])[C:5]([CH2:12][C:13]1[CH:18]=[CH:17][C:16]([I:19])=[CH:15][CH:14]=1)(C)[C:6](OCC)=O)C.[OH-].[Na+]>CCO>[I:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][CH:5]([CH3:6])[C:4]([OH:20])=[O:3])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66692023HCID 66692023, compound

Product 1

HCID 23219055HCID 23219055, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 2.30 g (5.89 mmol) 2-(4-iodo-benzyl)-2-methyl-malonic acid diethyl ester (V.1) in 30 mL EtOH are added 30 mL 1N NaOH. The mixture is stirred at reflux for 2 h. The solvent is evaporated and 35 mL 4N HCl are added. The mixture is stirred at 60° C. for 12 h. The solid is filtered off to yield the desired product.

Workup

  1. temperatureat reflux for 2 h
  2. customThe solvent is evaporated
  3. addition35 mL 4N HCl are added
  4. stirringThe mixture is stirred at 60° C. for 12 h
  5. filtrationThe solid is filtered off

Sources & evidence

ORD record
ord-b9172d68a31747af95bd9af9fc0eb6ad
Source dataset
uspto-grants-2014_11
Patent number
US08877754B2

Reaction notes

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