反应详情

21 g (200 mmol) of 4-methyl-3-thiosemicarbazide in 1000 mL of acetone was heated at reflux for 2 hours. To this solution was then added dropwise 20.4 g (220 mmol) of chloroacetone. The reaction mixture was allowed to reflux for 7 hours and was then concentrated. The resulting crude product was recrystallized from acetone. This gave 23 g of an orange-colored powder (63% of the theoretical).

1. temperatureat reflux for 2 hours
2. temperatureto reflux for 7 hours
3. concentrationwas then concentrated
4. customThe resulting crude product was recrystallized from acetone