反应详情

0.34 mL (3.5 mmol) acetic anhydride are added to 750 mg (3.22 mmol) 4-iodo-benzylamine in 15 ml acetic acid and the mixture is stirred at rt for 4 h. After that time, the solvent is evaporated and the residue partitionated between TBME and water. The organic layer is separated, washed with water (1×) and saturated NaHCO3 solution (2×). The organic layer is dried over sodium sulphate and the solvent is evaporated to yield the desired product.

1. customAfter that time, the solvent is evaporated
2. customThe organic layer is separated
3. washwashed with water (1×) and saturated NaHCO3 solution (2×)
4. dry with materialThe organic layer is dried over sodium sulphate
5. customthe solvent is evaporated