HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 330833Generated: October 28, 2026
1-Bromopropane → 1-Bromo-2-methoxy-4-propoxybenzene
https://huagongshe.com/reaction/330833
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-3-methoxyphenol | HCID 347955 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Bromo-2-methoxy-4-propoxybenzene | HCID 19594935 | — |
Reaction Steps
1.50 g (7.39 mmol) 4-bromo-3-methoxy-phenol are added to 1.36 g (11.1 mmol) 1-bromopropane in 10 mL DMF. 2.04 g (14.8 mmol) K2CO3 are added and the mixture is stirred at 80° C. for 12 h. After that time, the mixture is diluted with water and extracted with DCM. The organic layer is dried over sodium sulphate and the solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08877754B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-9a1efe617e9941eab7eea8d90018e4c0 |
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| Source note | uspto-grants-2014_11 |
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