N-(4-nitrophenyl)-N-(2-pyrid-3-ylethyl)amine → n-(2-Pyrid-3-ylethyl)benzene-1,4-diamine

HRID 33087Notes

Reaction equation

HRID 33087 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:6][CH:5]=1)([O-])=O>C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[Zn].[Cl-].[NH4+].O.C(O)C>[N:15]1[CH:16]=[CH:17][CH:18]=[C:13]([CH2:12][CH2:11][NH:10][C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=1

Participants

4

Reactant 1

HCID 23104837N-(4-nitrophenyl)-N-(2-pyrid-3-ylethyl)amine

Product 1

HCID 23104841n-(2-Pyrid-3-ylethyl)benzene-1,4-diamine

Reagents, catalysts & solvents 2

HCID 131726756ZINC ammonium chloride water ethanolCatalystHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideSolvent

Procedure

The N-(4-nitrophenyl)-N-(2-pyrid-3-ylethyl)amine (3) obtained above was reduced with a boiling zinc/ammonium chloride/water/ethanol mixture. The corresponding amine was isolated in dihydrochloride form.

Sources & evidence

ORD record
ord-9f8aa82056764152935ff01ad6fff2cd
Source dataset
uspto-grants-2008_09
Patent number
US07429278B2

Reaction notes

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