Methyl iodide → 4-chloro-3-iodo-1,6-dimethyl-1H-pyrrolo[2,3-b]pyridine

HRID 330999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 330999
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[NH:9][CH:10]=[C:11]([I:12])[C:3]=12.[H-].[Na+].[CH3:15]I>C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[N:9]([CH3:15])[CH:10]=[C:11]([I:12])[C:3]=12

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 710904044-chloro-3-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 710902764-chloro-3-iodo-1,6-dimethyl-1H-pyrrolo[2,3-b]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

In a round bottom flask under N2 gas, 4-chloro-3-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine (D12) (1.48 g, 5.06 mmol) was dissolved in THF (25 mL) and cooled to 0° C. To this was added NaH (0.405 g, 10.12 mmol) portion wise. After 30 minutes of stirring, methyl iodide (0.633 mL, 10.12 mmol) was added and the reaction mixture was stirred at 0° C. for 30 mins and at RT for 1 hour.

Aufarbeitung

  1. stirringthe reaction mixture was stirred at 0° C. for 30 mins and at RT for 1 hour

Quellen und Nachweise

ORD-Eintrag
ord-aa1c99462aaf431a88144960a86fa4cc
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877742B2

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