2-(5-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-1-yl)ethanol → 2-(6-(4-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-1H-indol-1-yl)ethanol

Participants

Role	Name	HCID	Charge
Reactant	2-(5-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-1-yl)ethanol	HCID 71090109	—
Reactant	4-bromo-3-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridine	HCID 71090148	—
Product	2-(6-(4-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-1H-indol-1-yl)ethanol	HCID 86720288	—

Reaction Steps

The title compound was prepared from 2-(5-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-1-yl)ethanol (D79) and 4-bromo-3-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridine (D7) using a similar procedure to that described for D8. LCMS (A): m/z (M+H)+ 388/390, C18H15BrFN3O requires 387/389 (acidic).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08877742B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-f2d85cfd3af34acbb028f5f7ca4f9fcb
Source note	uspto-grants-2014_11