Sodium Hydroxide → HCID 71090365, compound

Participants

Reaction Steps

To a suspension of methyl 3-(2-fluoro-5-(pyrrolidin-1-yl)phenyl)-1-methyl-4-(phenylsulfonamido)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (47 mg, 0.092 mmol) in MeOH (1 mL) stirred under nitrogen at RT was added a aqueous solution of 6M sodium hydroxide (0.077 mL, 0.462 mmol) in one charge. The reaction mixture was stirred at 80° C. for 2 hours. The reaction mixture was cooled to RT and concentrated. The crude was purified on normal phase silica eluting with 2M ammonia in MeOH and DCM (0-50%) to give the title compound (35 mg). LCMS (A): m/z (M+H)+ 495, C25H23FN4O4S requires 494 (basic).

Provenance & Evidence