HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 331081Generated: October 30, 2026
Thionyl Chloride → 1-(3,3,3-Trifluoropropyl)piperidine-4-carbonyl chloride
https://huagongshe.com/reaction/331081
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 59333911 | HCID 59333911 | — |
| Product | 1-(3,3,3-Trifluoropropyl)piperidine-4-carbonyl chloride | HCID 59333934 | 68% |
Reaction Steps
A suspension of 1-(3,3,3-trifluoropropyl)piperidine-4-carboxylic acid (4.40 g, 20.0 mmol) in thionyl chloride (20 mL) was heat to 80° C. for 15 h. The solution was cooled and concentrated in vacuo to yield a brown foam (3.0 g, 68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08877761B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-24609cee610845f38a3cfbb85d1dae6e |
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| Source note | uspto-grants-2014_11 |
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