HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[3-(4-Chloro-phenoxy)-benzyl]-piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4-[3-(4-Chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 67413541 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[3-(4-Chloro-phenoxy)-benzyl]-piperazine hydrochloride | HCID 67413809 | 211.7% |
Reaction Steps
A solution of 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester (29.6 g, 73.5 mmol) in 4:1 dioxane:H2O (100 mL) was treated with 4 M HCl in dioxane (60 mL). After 3 h, THF (200 mL) was added and the resulting white precipitate was filtered and dried under vacuum to give 1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride (26.4 g, 95%). MS (ESI+): calcd for C17H19ClN2O m/z 302.12, found 303.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877769B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f795602b1ab64b009dcf27a6892b050c |
| Source note | uspto-grants-2014_11 |