Heptane → HCID 58563115, compound

Participants

Reaction Steps

Prepared in a manner analogous to that described for intermediate B6.1 from (R)-ethyl 2-(4-amino-4-(5-bromo-2,4-difluorophenyl)-3,3-difluoro-2-methylpentan-2-yloxy)acetate (intermediate B5.2) (16.1 g; 37.4 mmol). After silica gel column chromatography with heptane and ethyl acetate as the eluent the (R)-5-(5-bromo-2,4-difluorophenyl)-6,6-difluoro-5,7,7-trimethyl-[1,4]oxazepan-3-one (9.0 g, 23.4 mmol, 63% yield) was obtained as an off-white solid. MS: m/z=384.2 [(M+H)+] and 386.1 [(M+2+H)+].

Provenance & Evidence