Lawesson's reagent → HCID 86671876, compound

Participants

Reaction Steps

The reaction of (R)-6,6-difluoro-5,7,7-trimethyl-5-(4,3′,5′-trifluoro-biphenyl-3-yl)-[1,4]oxazepan-3-one (159 mg, 398 μmol) with Lawesson's reagent (131 mg, 319 μmol) in 1,4-dioxane (13 ml) yielded the (R)-6,6-difluoro-5,7,7-trimethyl-5-(4,3′,5′-trifluoro-biphenyl-3-yl)-[1,4]oxazepan-3-thione (142 mg, 86% yield) as a white foam. MS (ISP): m/z=416.2 [M+H]+.

Provenance & Evidence