HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one | HCID 68380531 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-thione | HCID 86671881 | 81% |
Reaction Steps
The reaction of (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-one (244 mg, 657 μmol) with Lawesson's reagent (266 mg, 657 μmol) in 1,4-dioxane (20 ml) yielded the (R)-6,6-difluoro-5-(2-fluoro-5-(tetrahydro-2H-pyran-4-yl)phenyl)-5,7,7-trimethyl-1,4-oxazepan-3-thione (205 mg, 81% yield) as a white foam. MS (ISP): m/z=388.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877744B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-fe1d8739c07545e69cb995868c9fac9a |
| Source note | uspto-grants-2014_11 |