Lawesson's reagent → HCID 86671885, compound

Participants

Reaction Steps

The reaction of 3′-((R)-6,6-difluoro-5,7,7-trimethyl-3-oxo-[1,4]oxazepan-5-yl)-4′-fluoro-biphenyl-3-sulfonic acid 2,2-dimethyl-propyl ester (124 mg, 241 μmol with Lawesson's reagent (97.7 mg, 241 μmol) in 1,4-dioxane (10 ml) yielded the 3′-((R)-6,6-difluoro-5,7,7-trimethyl-3-thioxo-[1,4]oxazepan-5-yl)-4′-fluoro-biphenyl-3-sulfonic acid 2,2-dimethyl-propyl ester (115 mg, 90%) as a white foam. MS (ISP): m/z=530.2 [M+H]+.

Provenance & Evidence